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Whole Genome Sequencing of Fibrin Clots
Neutrophil Extracellular Traps, SERPINs and amyloidogenic variants of concern
https://open.substack.com/pub/anandamide/p/whole-genome-sequencing-of-fibrin
ANANDAMIDE 2025.05.23 Fri
https://substack.com/@kevinmckernan
There have been several reports of extreme clotting post mRNA vaccination. Many of the images of these clots have circulated on social media and have drawn scrutiny and accusations of these clots being manufactured in a lab or taken from animals to confuse the public on this important topic. In order to confirm these clots were in fact human derived we performed qPCR of the human house keeping gene RNaseP and followed that up with Whole Genome Sequencing. Both qPCR and Illumina whole genome sequencing confirm this is in fact human DNA. Human DNA is commonly found in clots due to a process known as Neutrophil Extracellular Traps or NETs. Evidence of these are reflected in the sequencing library. 27 clotting and thrombosis related genes were examined for variants that may predispose the patient to this phenomenon. Several moderate compounding mutations are found in Factor V, Factor XIIIB, Factor 7, and GP1BA. An additional 2312 genes with Gene Ontology annotations related to thrombosis were examined for variants of high impact with snpEFF. Several variants in SERPINs, CPB2, and MASP1 were identified in clots from 2 different individuals. Finally, 201 gene with Gene Ontology annotations related to amyloidogenesis were examined for high impact variants. Variants in PSEN2 and LRP1 were identified.
Introduction
SNIP
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